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September 18, 1937

Le traitement du diabète infantile par l'insuline

JAMA. 1937;109(12):980. doi:10.1001/jama.1937.02780380064029

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This is an excellent summary not only of the use of unmodified insulin in juvenile diabetes but of the dietary treatment and course of the disease. It is divided into four parts, consisting of a discussion of dietary treatment, indications and use of insulin, the accidents of insulin, the indication for insulin therapy in the course of special conditions and end results in treatment. The author believes that practically all cases of juvenile diabetes should be treated with insulin and with a quantitative diet, which prevent the progression of the disease and its complications. He discusses all the dietary forms of treatment, including an unusually good discussion of Stolte's diet. He refers to Allen's experiments of producing degeneration islets by overfeeding and the experiments of La Coste and Saric, who, by undernutrition and insulinization of normal persons, produced a depression of endogenous insulin output. He concludes that a middle course

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