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Article
March 26, 1932

A SPECIFIC HEMATOPOIETIC HORMONE IN NORMAL GASTRIC JUICE: PRELIMINARY NOTE

Author Affiliations

CINCINNATI

From the Department of Internal Medicine, University of Cincinnati College of Medicine, and the Medical Clinic, Cincinnati General Hospital.

JAMA. 1932;98(13):1080-1081. doi:10.1001/jama.1932.02730390034009
Abstract

The researches of Castle and his co-workers1 have thrown important light on the rôle of achylia gastrica in pernicious anemia and represent the most important advance in the study of this disease since the introduction and development of liver therapy by Minot and his associates.

It has been shown by Castle that the gastric juice in pernicious anemia is lacking in some vital factor. He has found that when beef which has been digested by normal gastric juice is fed to the patient ill with pernicious anemia, a reticulocyte response occurs within ten days, comparable to that obtained with liver therapy. If, on the other hand, the beef is digested with the gastric juice from a patient ill with pernicious anemia, its ingestion no longer stimulates an increase in the reticulocytes. The same negative result was obtained when beef predigested by artificial gastric juice was given to patients with

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