The researches of Castle and his co-workers1 have thrown important light on the rôle of achylia gastrica in pernicious anemia and represent the most important advance in the study of this disease since the introduction and development of liver therapy by Minot and his associates.
It has been shown by Castle that the gastric juice in pernicious anemia is lacking in some vital factor. He has found that when beef which has been digested by normal gastric juice is fed to the patient ill with pernicious anemia, a reticulocyte response occurs within ten days, comparable to that obtained with liver therapy. If, on the other hand, the beef is digested with the gastric juice from a patient ill with pernicious anemia, its ingestion no longer stimulates an increase in the reticulocytes. The same negative result was obtained when beef predigested by artificial gastric juice was given to patients with
MORRIS RS, SCHIFF L, BURGER G, SHERMAN JE. A SPECIFIC HEMATOPOIETIC HORMONE IN NORMAL GASTRIC JUICE: PRELIMINARY NOTE. JAMA. 1932;98(13):1080–1081. doi:10.1001/jama.1932.02730390034009
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