The year 2021 was again tumultuous for the health care profession and for everyone affected by the coronavirus pandemic, but was a boon for graphic medicine. In this essay we highlight 2 exceptional graphic memoirs that explore how illness is experienced and remembered, reconstructed, and retold. Though very different in their approaches, both welcome readers into unusual and strange worlds, facilitating the vicarious experience of unfamiliar illness. In doing so, they show how one rebuilds after facing (and accepting) a sometimes radically new reality.