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October 9, 1937


JAMA. 1937;109(15):1163-1166. doi:10.1001/jama.1937.02780410001001

The treatment of syphilis of the central nervous system is still in a developmental phase. We have passed through the trial era of specific treatment and have now had sufficient experience with nonspecific measures to crystallize our concepts of their therapeutic value. In appraising the results of treatment I have followed the classification of neurosyphilis (given in the accompanying table) adopted by the Committee on Nonspecific Therapy of Neurosyphilis.1

ASYMPTOMATIC NEUROSYPHILIS  The report2 of the Cooperative Clinical Group shows that the results of treatment of asymptomatic neurosyphilis are less encouraging than the reviews of smaller groups of cases had indicated. The survey indicates that the results of treatment are dependent on the severity of the spinal fluid reaction as well as on the type and amount of treatment administered after the diagnosis of asymptomatic neurosyphilis has been made.The incidence of asymptomatic neurosyphilis is twice as common in

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