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October 9, 1937


JAMA. 1937;109(15):1202. doi:10.1001/jama.1937.02780410040011

Laboratory studies on the effects of dietary factors in nephritis have been stimulated by Masugi's1 recent demonstration that chronic nephritis, closely resembling human Bright's disease, can be induced in laboratory animals by the intravenous injection of a properly selected organ-specific nephrotoxic serum. This work has apparently been confirmed by Smadel and Farr2 at the Rockefeller Institute for Medical Research, who studied3 the effects of high protein diets on experimental chronic nephritis produced by this means in rats. These investigators studied the renal function, plasma proteins and hemoglobin of forty-eight young rats on routine laboratory diets. Severe nephritis was then produced in these rats by intravenous injections of the Masugi organ-specific antikidney serum. The animals were then divided into three groups, which were subsequently fed on three different isocaloric diets. Each diet contained 27 per cent fat (Crisco), 4 per cent salt mixture and adequate vitamins. In addition,