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April 2, 1932


JAMA. 1932;98(14):1197-1198. doi:10.1001/jama.1932.02730400075021

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The Value of Tuberculin in Diagnosis  The medical research council has published a research by Dr. P. D'Arcy Hart, assistant to the medical unit, University College Hospital, London, who has observed the reactions to tuberculin of 1,030 clinically tuberculous and 731 nontuberculous patients of all ages. He finds that the tuberculin test is one of scientific accuracy, provided the intracutaneous method of Mantoux and not the cutaneous one of Pirquet is adopted. The positive reactions are not yet susceptible of such quantitative grading as might serve to distinguish active tuberculosis, as such, from the benign results of infection that has at some time or another been implanted in most members of an urban population. A negative reaction, following an adequate dosage of tuberculin, is at all ages of diagnostic value for excluding tuberculous disease, the error being only about 2 per cent. The negative reaction is most likely to be

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