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October 16, 1937

PROPHYLACTIC VACCINATION AGAINST INTRACRANIAL COMPLICATIONS: FOLLOWING PNEUMOCOCCUS TYPE III MASTOIDITIS

Author Affiliations

NEW YORK

From the Laboratories and the Otological Service of the Mount Sinai Hospital.

JAMA. 1937;109(16):1254-1257. doi:10.1001/jama.1937.02780420014004
Abstract

It is well known that the presence of the type III pneumococcus in acute mastoiditis offers a serious prognosis because of the frequency with which subsequent intracranial complications develop. Meningitis is the complication usually encountered. As there is an interval of from one to several weeks, as a rule, between the initial infection and the time when complications occur, attempts to induce a state of active acquired immunity should receive consideration.

A number of workers in recent years have been able to protect animals against pneumococcic infections in a short period by vaccination. The following are some of the significant and pertinent reports on the subject:

Barach1 in 1928 showed that mice can be actively immunized in three days by a single intraperitoneal injection of types I and II pneumococcus vaccine. In his experiments, type-specific antibodies appeared on the third day, increased progressively until the fifth day and remained

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