It is well known that the presence of the type III pneumococcus in acute mastoiditis offers a serious prognosis because of the frequency with which subsequent intracranial complications develop. Meningitis is the complication usually encountered. As there is an interval of from one to several weeks, as a rule, between the initial infection and the time when complications occur, attempts to induce a state of active acquired immunity should receive consideration.
A number of workers in recent years have been able to protect animals against pneumococcic infections in a short period by vaccination. The following are some of the significant and pertinent reports on the subject:
Barach1 in 1928 showed that mice can be actively immunized in three days by a single intraperitoneal injection of types I and II pneumococcus vaccine. In his experiments, type-specific antibodies appeared on the third day, increased progressively until the fifth day and remained
GOLDMAN JL, HERSCHBERGER C. PROPHYLACTIC VACCINATION AGAINST INTRACRANIAL COMPLICATIONSFOLLOWING PNEUMOCOCCUS TYPE III MASTOIDITIS. JAMA. 1937;109(16):1254–1257. doi:10.1001/jama.1937.02780420014004
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