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November 13, 1937


JAMA. 1937;109(20):1654. doi:10.1001/jama.1937.02780460064025

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To the Editor:—  It seems unfortunate that the interesting experiments of Farr and Smadel on the influence of diet on rats suffering from experimentally produced nephritis should have been so emphasized in the editorial columns of The Journal (October 9, p. 1202) that the reader is given the impression that anything more than a very low protein diet may well prove disastrous for the human patient with nephritis. Aside from the possible differences between rats and men, the experiments as they stand, if transferred to human patients, would lead to no such conclusion.As the figures are quoted, the diet lowest in protein, and on which the nephritic rats seemed to thrive, consisted of "salt mixture" 4 per cent, protein 5 per cent, fat 27 per cent and carbohydrate 64 per cent, plus adequate vitamins. For a man weighing 100 pounds (45 Kg.) one would have to give a diet

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