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November 13, 1937

Urovskaya bolezn v Zabaykale. Vypusk vtoroy

JAMA. 1937;109(20):1664. doi:10.1001/jama.1937.02780460074044

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The present is the second volume of collected papers published by the Urovsk Scientific Institute. A large number of the population of this Far Eastern territory had been known for the past century to exhibit signs of a peculiar disorder of the joints to which the original investigators, Kashin and Bek, gave the name of endemic deforming osteo-arthritis. The incidence of endemic goiter is particularly high and the two conditions are frequently associated. Kashin-Bek, or Urovsk, disease is characterized by a chronic progressive course with symmetrical involvement and deformation of joints and epiphyses of the long bones, particularly the extremities. The disease is associated with a peculiar form of a genuine congenital rickets and with pathologic alterations in the lymph nodes, the thyroid, thymus, spleen and the vascular system. The tendency of the disease is to progression and deformation of the osseous and muscular systems. A relative avitaminosis, lack of

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