Regular use of phosphodiesterase type 5 inhibitors (PDE5Is) for erectile dysfunction was associated with increased risks of serous retinal detachment (SRD), retinal vascular occlusion (RVO), and ischemic optic neuropathy (ION) among older US men in a large observational study. PDE5Is are among the most prescribed medication classes in the US and include avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).