The pathogenesis of angioneurotic edema is unknown. Ten years ago the chief emphasis was placed on the vasomotor and neurotic background. Since that time, however, the vasomotor and neurotic background has been receiving progressively less consideration, and increasing emphasis has been placed on allergy. Certainly, from the standpoint of successful treatment, when an offending substance, food or protein, is shown to be the cause of an angioneurotic edema it should be removed, or there should be attempts made to desensitize the patient. But from the impression gained in reviewing the literature, and from my own experience, attempts to eliminate the offending substance and to desensitize have been largely unsuccessful. Consequently it would seem that this emphasis on the allergic background of angioneurotic edema is of small use from the practical therapeutic point of view. Perhaps the greater emphasis should rest on the older view that angioneurotic edema is a vasomotor
Klinefelter EW. EFFECTIVE USE OF EPINEPHRINE INHALATIONS IN ANGIONEUROTIC EDEMA. JAMA. 1937;109(22):1798–1799. doi:10.1001/jama.1937.92780480001008
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