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June 3, 2022

Bariatric Surgery and Cancer Risk

Author Affiliations
  • 1Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
JAMA. 2022;327(24):2400-2402. doi:10.1001/jama.2022.9166

Approximately 42% of adults in the US have obesity, with a body mass index of 30 or greater.1 Obesity has been shown to be associated with multiple types of cancer (including postmenopausal breast, endometrial or uterine, ovarian, esophageal adenocarcinoma, gallbladder, gastric cardia, colorectal, renal cell, liver, pancreas, thyroid, meningioma, multiple myeloma) and these are referred to as obesity-associated cancers.2 Obesity promotes and accelerates cancer by multiple mechanisms, including increases in circulating adipokines, insulin and insulin growth factor, circulating estrogens, inflammatory cytokines, changes in microbiota, and epigenetic changes.

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