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JAMA Clinical Guidelines Synopsis
July 11, 2022

Obesity and Weight Management for Prevention and Treatment of Type 2 Diabetes

Author Affiliations
  • 1University of Chicago, Chicago, Illinois
JAMA. 2022;328(4):389-390. doi:10.1001/jama.2022.10338

Type 2 diabetes is a disease characterized by insulin resistance and pancreatic β-cell dysfunction resulting in hyperglycemia. An estimated 34 million people in the US (about 1 in 10) have diabetes, of whom an estimated 90% to 95% have type 2 diabetes.1 The risk of type 2 diabetes increases with obesity, and weight loss is associated with improved glycemic control. Both obesity and type 2 diabetes increase risk of cardiovascular disease, a leading cause of death in the US.

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