In 1935 the literature related to the pathologic changes incident to exposure to heat was reviewed, and the lesions produced by accurately controlled fever therapy in two human beings and twenty experimental animals were reported.1 Briefly, the pathologic changes noted may be summarized as follows: Gross changes consisted of engorgement and congestion of blood vessels, degeneration and hemorrhage of the adrenals, hemorrhages in the brain, marked edema and congestion of the lungs, contraction and bloodlessness of the intestine and parenchymatous degeneration of the liver and kidneys. Microscopically, acute passive congestion of all the organs and tissues and cellular degeneration and hemorrhages of varying degree in the adrenals, liver, brain, lungs and kidneys were visible.
At the time of the previous report no attempt was made to determine the etiology and the pathogenesis of the lesions described; it was assumed that they were due to the heat applied, and it
HARTMAN FW. LESIONS OF THE BRAIN FOLLOWING FEVER THERAPY. JAMA. 1937;109(26):2116–2121. doi:10.1001/jama.1937.02780520006002
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