There has been an increasing display of enthusiasm for the nonspecific therapy of syphilis during the past ten years. It is readily acknowledged that the credit for this development belongs to Wagner von Jauregg.1 His demonstration of the efficiency of malarial therapy of dementia paralytica precipitated a world-wide search for other measures that might be of value in the treatment of patients who manifested the resistant types of syphilis. The effort to develop these more efficient remedies was stimulated not only by the results of Wagner von Jauregg's experience but also because syphilologists had learned of the therapeutic accomplishments as well as the therapeutic limitations of the arsenical drugs and the heavy metals. For a decade following the introduction of arsphenamine the effort to produce cures by the use of this new specific was so great that the patient's defensive mechanism, which is the potent factor in the cure
O'LEARY PA. NONSPECIFIC TREATMENT OF SYPHILISCLINICAL LECTURE AT ATLANTIC CITY SESSION. JAMA. 1938;110(1):42–45. doi:10.1001/jama.1938.62790010005010
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