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Article
May 7, 1932

THE TREATMENT OF PERNICIOUS ANEMIA WITH HORSE LIVER EXTRACT: PRELIMINARY REPORT

JAMA. 1932;98(19):1623-1625. doi:10.1001/jama.1932.02730450017003
Abstract

The value of cattle liver and desiccated hog stomach in the treatment of pernicious anemia is established. The "active principle" has been reported to be present in a number of tissues.1

Our work was undertaken to determine (1) whether horse liver contains the antianemic principle active in pernicious anemia, and (2), if so, its relative concentration or potency. A positive finding would increase the commercial source of liver, since many horses are slaughtered daily at Rockford, Ill., and the meat packed for human and canine consumption; and it is possible that the yield from horse liver might be greater and the extract lend itself more readily to purification and concentration. It is also possible that horse liver extract might prove to be more efficacious on oral administration and hence render the necessity of intramuscular injections unnecessary in those patients who do not respond to cattle liver given orally.2

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