At present it is common practice to provide active immunization for all infants and children of preschool age with toxin-antitoxin mixtures or toxoid, without a preliminary Schick test. Various ages have been suggested during infancy as the most desirable time to begin such immunization. In an extensive campaign of advertising, a prominent life insurance company recommends, under the caption "Six Months Old Today," that the infant be taken to the physician at that age, to be actively immunized against diphtheria. Posters may be seen in welfare agencies and baby health stations, recommending that the child be immunized on its first birthday. In view of these practices, an investigation was undertaken to determine the proper age when active immunization should be instituted. An exceptional opportunity was afforded to carry out this work at the Home for Hebrew Infants, where the children are under observation for three or four years and can
BLUM J. AGE FACTOR IN ACTIVE IMMUNIZATION OF INFANTS AGAINST DIPHTHERIA. JAMA. 1932;98(19):1627–1629. doi:10.1001/jama.1932.02730450021005
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