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January 22, 1938

THE TOXICITY OF SULFANILAMIDE

Author Affiliations

BALTIMORE

From the Department of Pharmacology and Experimental Therapeutics, the Johns Hopkins University School of Medicine.

JAMA. 1938;110(4):252-257. doi:10.1001/jama.1938.02790040006002
Abstract

Despite the widespread use of sulfanilamide (paraaminobenzenesulfonamide) in the treatment of certain bacterial infections, very scanty data are available concerning its toxicity for animals. Several observers have reported on its toxicity, using very limited numbers of animals. Buttle and his co-workers,1 giving the drug in acacia suspension by mouth, state that 2.5 Gm. per kilogram is innocuous, 4 Gm. is tolerated but produces incoordination and paralysis, 5 Gm. kills two of six mice, and 10 Gm. kills six of six mice. Rosenthal2 reports that, administered subcutaneously in olive oil suspension, 4 Gm. per kilogram killed none of five mice, while 6 Gm. per kilogram killed three of four mice. Chen3 found the L. D.504 for mice by intravenous injection to be from 0.35 to 0.40 Gm. per kilogram. Raiziss and his co-workers5 report that 2.5 Gm. per kilogram by subcutaneous injection kills six of

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