A shorter course of oral doxycycline is effective in treating erythema migrans, the most frequent manifestation of early Lyme borreliosis, and can reduce harmful antibiotic use, trialists recently reported.
The trial, conducted in Slovenia, randomly assigned 300 adults with solitary erythema to receive oral doxycycline, 100 mg twice a day for 7 or 14 days. Doxycycline for 10 days is the primary treatment recommendation for erythema migrans, the investigators noted.