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This "supplement" brings to the present the subjects which it treats. There are included the atropine group, saccharin, the posterior pituitary, the parathyroid, arsenic and antimony and their compounds. While the chief emphasis is on experimental pharmacodynamics, one finds in it many items of practical therapeutic value. Thus there is warning against the use during excessive heat of drugs containing atropine, because they interfere with heat regulation by checking perspiration. The increased pulse rate produced by them may be disadvantageous in arteriosclerotic and syphilitic diseases of the heart. The large doses of atropine now advocated in parkinsonism may produce habituation. A review of the experimental evidence proves the harmlessness of saccharin. It would take a chronic ingestion of more than 5 to 10 Gm. a day before harm would result, and this would be chiefly in the form of intestinal irritation. To the two active principles of the posterior lobe
Handbuch der experimentellen Pharmakologie. JAMA. 1938;110(5):392. doi:10.1001/jama.1938.02790050070025
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