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January 29, 1938

Handbuch der experimentellen Pharmakologie

JAMA. 1938;110(5):394. doi:10.1001/jama.1938.02790050072034

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This small volume by Clark represents an effort to organize the subject of interactions between drugs, as chemicals, and cells on the basis of known and applicable laws of physical chemistry. However, the author fully realizes "that physicists and chemists have applied mathematical methods of analysis to data obtained by biologists without realizing the inaccuracy of the data which they have treated, and have obtained proofs of the occurrence of biological impossibilities, and these proofs have been accepted by biologists who have been impressed, if not mesmerized, by the imposing formula provided." The author has limited his concern chiefly to the simplest of available systems, such as enzymes and unicellular organisms, in relation to drugs. He takes up, among other subjects, reactions between drugs and proteins, drugs and enzymes, kinetics of drug action on cells, synergism and antagonism, and quantitative aspects of chemotherapy. In no sense can the book be

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