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February 12, 1938

THE CONTROL OF MENINGOCOCCIC MENINGITIS EPIDEMICSBY ACTIVE IMMUNIZATION WITH MENINGOCOCCUS SOLUBLE TOXIN: FURTHER STUDIES

JAMA. 1938;110(7):484-487. doi:10.1001/jama.1938.02790070008003
Abstract

In July 1936 the senior author1 reported observations on the control of epidemics of meningococcic meningitis by active immunization with the soluble toxin in the filtrate from meningococcus broth culture. The full strength filtrate was given subcutaneously in 0.2, 0.5, 1 and 1.5 cc. amounts at four day intervals as early as possible in five outbreaks.

The fact that no further cases occurred in epidemics in which it had been given and that intradermal reactions changed from positive before inoculation toward negative after inoculation2 caused us, during the past year, to give the toxin a prophylactic trial among the CCC enrollees in the state of Missouri and to use it for the purpose of control in as many incipient epidemics as possible. The results of this work are here described.

THE VALUE OF INTRADERMAL TESTING AND PROPHYLACTIC IMMUNIZATION  To determine the value of the intradermal test for separating

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