Dangers incident to forcing fluids have frequently been described in the literature, and fatal complications have been recorded. In 1936 we 1 described the first case of fatal water intoxication resulting from the administration of large quantities of tap water by proctolysis. We were able to reproduce in animals the clinical and pathologic picture that we found in our patient as well as the chemical alterations in the tissues by administering tap water into the rectums of rabbits. In the same communication the mechanism by which water intoxication is produced was discussed and a method by which it might be relieved was presented. In our first case we did not recognize the condition clinically, and it was proved to be an instance of water intoxication only after the postmortem examination. We have recently observed a second case of this condition which we recognized before it resulted fatally. Through proper therapy
Helwig FC, Schutz CB, Kuhn HP. WATER INTOXICATION: MORIBUND PATIENT CURED BY ADMINISTRATION OF HYPERTONIC SALT SOLUTION. JAMA. 1938;110(9):644–645. doi:10.1001/jama.1938.62790090004008c
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