Although life expectancy in industrialized countries has lengthened over the past century, increases in US life expectancy ceased after 2010, a trend attributed to rising mortality rates among individuals aged 25 to 64 years.1 Although midlife mortality rates increased over the past decade, mortality rates among children and older adults continued to decrease. The COVID-19 pandemic altered this trend and resulted in a sharp increase in mortality among older adults, an unsurprising outcome. However, pediatric mortality rates also increased, and COVID-19 contributed little to this surge. This increase in all-cause pediatric mortality has ominous implications. A nation that begins losing its most cherished population—its children—faces a crisis like no other.