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March 5, 1938

THROMBOCYTOPENIC PURPURA FOLLOWING ALLYLISOPROPYL-ACETYL-CARBAMIDE (SEDORMID)

Author Affiliations

Los Angeles

From the University of Southern California School of Medicine and the Los Angeles General Hospital.

JAMA. 1938;110(10):725-726. doi:10.1001/jama.1938.62790100001007
Abstract

The purpuric state has been classified by Leschke1 and modified by Pratt2 into the nonthrombocytopenic and the thrombocytopenic varieties. Of the latter, Werlhof's disease or essential thrombocytopenic purpura forms the larger group with the secondary or symptomatic thrombocytopenic purpura due to x-rays, radium, leukemia, benzene and arsphenamine comprising the remainder.

The etiology of purpura being manifold, further description of apparently authentic etiologic agents is justified.

Squier and Madison's3 description of three patients in whom definite thrombocytopenic purpura seemed related to food allergy is an example of this trend. Quinine sensitivity producing thrombocytopenia and purpura has been described by Maritschek and Markowicz4 and by Peshkin and Miller5 for quinine and ergot.

Sedormid (allyl-isopropyl-acetyl-carbamide) was first reported as suspect as an etiologic agent in thrombocytopenic purpura by Loewy6 in 1934. In one patient severe purpura with thrombocytopenia could be induced at will by the administration of

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