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This is a monographic report of extensive investigation of the internal function of the pancreas by means of blood sugar time curves. The investigation covered tests made on normal dogs, dogs with complete and partial pancreatectomy and dogs with the pancreas intact, which had been treated for prolonged periods with insulin. Clinical diabetes of various types was similarly investigated before and after fasting, and before and in the course of treatment with insulin. Microscopic examination of the pancreas of animals that had received insulin for several months revealed hyperplasia of the islands of Langerhans. Significant conclusions are that hyperglycemia is the physiologic excitant of the insular function, but overloading with sugar is depressing to the islands, the more so if they already are injured; that treatment with insulin by a splinting effect causes normally an increase of insular tissue and increased amount of stored insulin; that a regimen rich in
L'exploration fonctionnelle du pancréas interne. A l'état normal, dans le diabète sucré, dans le diabète du jeûne, et après insulinisation prolongée. Étude expérimentale et clinique. JAMA. 1938;110(10):763. doi:10.1001/jama.1938.02790100061033
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