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March 12, 1938


JAMA. 1938;110(11):796-799. doi:10.1001/jama.1938.02790110022007

The discoverer of the cathartic action of phenolphthalein, Zoltan von Vamossy,1 determined that more than 85 per cent of ingested phenolphthalein is eliminated in the dog's feces and that merely a minimal quantity of free phenolphthalein is occasionally to be found in the urine on the addition of alkali. He also noted in dogs, after the giving of enormous doses, an increase in the conjugated sulfates in the urine.2

Kastle probably was the first to discover the presence of conjugated phenolphthalein in the urine. After giving a dose of 0.5 Gm. of phenolphthalein intraperitoneally to a guinea pig he observed the excretion of conjugated phenolphthalein in the urine for twenty days.

Fleig3 studied exhaustively the fate of phenolphthalein in the system, and he as well as others concluded that phenolphthalein is so stable a compound that it is not decomposed into phenol and phthalic acid in the

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