From an etiologic aspect as well as from the standpoint of rarity, the occurrence of goiter in infants is of interest. It is known that the thyroid glands of infant cretins are often from two to five times normal size in endemic regions.1 The pathologic change in these glands is essentially a diffuse vascular or parenchymatous enlargement, according to Kaufmann,1 Boothby and Plummer2 and others. Aschoff3 and De Quervain4 mentioned diffuse hyperplasia of the thyroid in the new-born ("struma, diffusea neonatorum") and Helmholz5 has seen frank exophthalmic goiter in a child of 1 year.
We are not aware, however, of any reports in the literature of a single large encapsulated adenoma occurring in a newborn child. Pemberton6 has seen a diffuse adenomatous colloid goiter which was said to be present at birth. C. H. Mayo6 recently told one of us (Stevens) that
Stevens GA, Waite WW. NODULAR GOITER OF THE NEW-BORN WITH SUBSEQUENT ADENOCARCINOMA. JAMA. 1938;110(11):803–804. doi:10.1001/jama.1938.62790110005008c
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