About forty years ago, Hand discussed in the Transactions of the Philadelphia Pathological Society a peculiar clinical and anatomic picture characterized by xanthomatous lesions of the bones and polyuria. Since the case also presented signs of tuberculosis, he considered the xanthomatous changes tuberculous. Hand's observations were apparently not repeated until more than twenty years later. Then Schüller called attention to sharply defined geographic defects of the skull in young persons, with signs of dyspituitarism. A similar combination was observed by Christian, who outlined a symptom complex consisting of defects of the membranous bones, diabetes insipidus and exophthalmos. Cases more or less related to those described by Hand, Schüller and Christian had been published from time to time under different names and had been interpreted as being granulomatous or blastomatous in nature. With an intuitive feeling for causal relations, Rowland collected this material, grouped together the common features and, basing his
SCHÜLLER-CHRISTIAN DISEASE—A DISTURBANCE OF THE LIPID METABOLISM. JAMA. 1932;98(22):1887–1888. doi:10.1001/jama.1932.02730480037014
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