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June 4, 1932


Author Affiliations


From the Department of Medicine and the Department of Pathology, University of Minnesota Medical School.

JAMA. 1932;98(23):1974-1978. doi:10.1001/jama.1932.02730490020006

Subcutaneous injections of a streptococcic vaccine have been used extensively for many years in the treatment of arthritis. Both autogenous and stock vaccines have been tried. Some of the larger series of vaccinated patients have been those of Billings, Coleman and Hibbs,1 Crowe2 and Burbank.3 Crowe and Burbank have reported favorable results. Billings, Coleman and Hibbs compared results of a large series of vaccinated patients with a series of unvaccinated patients. In a follow-up study they found no significant differences in the incidence of improvement in the treated and untreated groups.

There are few reports on intravenous streptococcic vaccination in the literature. Clawson and Fahr4 reported the use of intravenous streptococcic injections in the treatment of rheumatic fever. Swift and his co-workers,5 injected Streptococcus hemolyticus intravenously in the treatment of rheumatic fever. We6 have used the intravenous method in administering a streptococcic vaccine in