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April 2, 1938

ABSORPTION OF DRUGS AND POISONS THROUGH THE SKIN

JAMA. 1938;110(14):1127. doi:10.1001/jama.1938.02790140059020

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Abstract

To the Editor:—  These comments are prompted by the report of David I. Macht's experiments (The Absorption of Drugs and Poisons Through the Skin and Mucous Membranes, The Journal, February 5, p. 409). Macht incorporated drugs in fixed fats, observed systemic reactions of the drugs, and concluded: "Such experiments revealed that none of the fixed fats carrying potent drugs were absorbed very readily." If writers on this subject would use the word "absorption" only when they refer to absorption of substances into the blood stream, and "penetration" only when they refer to penetration of substances into or through the skin, much confusion and also, sometimes, faulty deductions would be avoided. Macht, of course, is speaking of penetration into the skin, for certainly he would not expect a fixed fat to be absorbed into the circulation through the skin.Macht believes that his results should have "great practical significance, particularly to

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