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It is probable that the total occurrence of cases of true porphyria congenita in Europe and the United States since Günther's paper in 1911 is less than the number of papers that have been written on the subject. In the last decade, however, it has been gradually recognized that the porphyrins are of more significance to medicine than association with some pathologic curiosities. Porphyrins are fundamental components of the hemoglobins and at least some of the oxidation catalysts (cytochrome C) as well as of the chlorophylls. The brilliant chemical studies of Hans Fischer and the spectroscopic work of Dhéré have not escaped the attention of clinical investigators, especially in Germany, who are studying porphyrin metabolism in a wide variety of conditions. Reviews on the clinical significance of the porphyrins have been published recently by J. T. Brugsch (Ergebn. d. ges. Med.20:423, 1935; Ergebn. d. inn. Med. u. Kinderh
Porphyrine und Porphyrinkrankheiten. JAMA. 1938;110(14):1138. doi:10.1001/jama.1938.02790140070034
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