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April 9, 1938

The Laboratory Diagnosis of Syphilis: The Theory, Technic, and Clinical Interpretation of the Wassermann and Flocculation Tests with Serum and Spinal Fluid

JAMA. 1938;110(15):1221. doi:10.1001/jama.1938.02790150067035

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In his attack on the rather considerable task to which he set himself (as detailed in the subtitle) the author of this monograph maintains a high degree of objectivity. He does not attempt to "prove" anything and thus succeeds' in establishing a body of carefully documented facts and skilfully drawn conclusions which should be of great service to the practicing clinician and serologist, and of use to the investigator. The text is composed of a historical introduction, six parts and five appendixes, and concludes with a selected bibliography of approximately one thousand titles. Parts I and II deal with the basic physicochemical phenomena which underlie the application of the complement fixation test and the flocculation phenomenon to the serodiagnosis of syphilis. Each part ends with a description of acceptable technics for performing the respective types of test. In addition, part II contains a searching critical examination of the methods for

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