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April 16, 1938

Lipogenesis in the Animal Body, with Special Reference to the Physiology of the Goose

JAMA. 1938;110(16):1311-1312. doi:10.1001/jama.1938.02790160069029

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This monograph presents the gathered ends of twenty-three years of sporadic investigation at the Carnegie Nutrition Laboratory on the metabolism of the goose, particularly with reference to the problem of fat formation. The collected work represents a mountain of labor and investment and the outcome appears to be a not very large body of new fact. The only new conclusion of fundamental significance, which is unfortunately supported by relatively meager data, seems to be that, contrary to expectation, one finds no difference in the calorific equivalent of oxygen by comparison of direct and indirect calorimetry, regardless of whether carbohydrate is being burned or being laid down as fat. This statement is in reality a denial of the laws of thermodynamics and is inherently improbable. It is supported by a scanty five observations which vary by 5 per cent among themselves, whereas the expected difference in the particular experiments is just

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