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Article
June 11, 1932

THE HISTAMINE FACTOR IN ANAPHYLAXIS

JAMA. 1932;98(24):2143. doi:10.1001/jama.1932.02730500109012
Abstract

The well defined differences in the anaphylactic syndrome in different species of animals suggests the necessity of developing various antianaphylactic therapies. This, however, would not be necessary if it could be shown that the experimental symptomatologies are but quantitative variants of the same basic clinical picture. Numerous experimenters have attempted to establish this basic unity. It has been suggested, for example, that the exceptionally high development of the bronchial musculature in the guinea-pig is the reason why anaphylaxis in this animal is of the asthmatic type. The unusually developed musculature of the hepatic veins of dogs is suggested as a reason why canine anaphylaxis is of the splanchnic-congestive type. Other experimenters have emphasized basic factors in the capillary endothelium and in the circulating blood.

A convincing contribution to this theory of clinical anaphylaxis is contained in Watanabe's 1 recent quantitative determinations of the comparative topographic distribution of histamine-like substances in

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