The purpose of this paper is to present a few of many observations made on cases of edema which have been influenced chiefly by the dietary mineral control. This material is offered only as evidence of the probable importance of the daily intake of sodium and potassium in the control of chronic cases of disturbed water balance of cardiac and renal origin.
It is not necessary to enter into a long discussion of sodium, potassium, the chlorides and acid-base equilibrium, which have been so ably discussed by Blum, Widal, Bunge, Peters, Van Slyke, Keith and many others included in the editorials of The Journal. It is sufficient to say that there have been repeated statements of the importance of sodium rather than the chlorides in fluid storage and that there is abundant evidence of the antagonistic or the displacing influence of sodium by potassium with a resultant fluid loss. However,
BARKER MH. EDEMA AS INFLUENCED BY A LOW RATIO OF SODIUM TO POTASSIUM INTAKE: CLINICAL OBSERVATIONS. JAMA. 1932;98(25):2193–2197. doi:10.1001/jama.1932.02730510019006
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