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May 21, 1938

GENTIAN VIOLET AS A THERAPEUTIC AGENT: WITH NOTES ON A CASE OF GENTIAN VIOLET TATTOO

Author Affiliations

Instructor in Dermatology, University of Kansas School of Medicine KANSAS CITY, MO.

JAMA. 1938;110(21):1733-1738. doi:10.1001/jama.1938.02790210013005
Abstract

New and Nonofficial Remedies, 1937,1 gives the information that the medicinally interesting derivatives of triphenylmethane and its homologue tolydiphenylmethane are those which result from the introduction of amino groups forming pararosaniline, (NH2C6H4)3COH, and rosaniline, (NH2C6H4)2 (CH3NH2C6H3).COH.

On treating rosaniline with hydrochloric acid, the hydroxyl of the carbinol group is split off, permitting the formation of the quinoid group, thus forming a typical dye known as fuchsin, NH2C6H4.CH3. NH2C6H3C:C6H4:NH2Cl. The red color of pararosaniline chloride or fuchsin is changed to violet by the entrance of a methyl group in the amino groups, the intensity of the violet color increasing with an increasing number of methyl groups. Thus, there are the

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