New and Nonofficial Remedies, 1937,1 gives the information that the medicinally interesting derivatives of triphenylmethane and its homologue tolydiphenylmethane are those which result from the introduction of amino groups forming pararosaniline, (NH2C6H4)3COH, and rosaniline, (NH2C6H4)2 (CH3NH2C6H3).COH.
On treating rosaniline with hydrochloric acid, the hydroxyl of the carbinol group is split off, permitting the formation of the quinoid group, thus forming a typical dye known as fuchsin, NH2C6H4.CH3. NH2C6H3C:C6H4:NH2Cl. The red color of pararosaniline chloride or fuchsin is changed to violet by the entrance of a methyl group in the amino groups, the intensity of the violet color increasing with an increasing number of methyl groups. Thus, there are the
SUTTON RL. GENTIAN VIOLET AS A THERAPEUTIC AGENT: WITH NOTES ON A CASE OF GENTIAN VIOLET TATTOO. JAMA. 1938;110(21):1733–1738. doi:10.1001/jama.1938.02790210013005
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: