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To the Editor:—
Ever since hypodermic medication has been used as substitution or immunization therapy, attempts have been made to replace it by oral administration. Naturally this should be our aim, since the ease of administration, lack of pain and possibly lower cost would make oral therapy more desirable. Oral immunization thus far with the majority of vaccines and specific antigens has not been accepted as successful. One of the newest forms of specific therapy of that type includes pollen. While some reports relative to the use of pollen orally were published fifteen years ago, in the last year or two the greatest attention has been given it. Several papers have dealt with the efficacy of pollen administered orally. One of the objections to the reports is that almost all of them concern territory which is essentially free from our major and most serious cause of hay fever—ragweed. The favorable
Lichtenstein MR. ORAL IMMUNIZATION IN ALLERGY. JAMA. 1938;110(23):1942–1943. doi:10.1001/jama.1938.02790230058025
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