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June 11, 1938

THE USE OF ZINC SULFATE SOLUTION FOR THE PREVENTION OF POLIOMYELITIS IN MAN

Author Affiliations

Stanford University, Calif. Department of Bacteriology and Experimental Pathology.

JAMA. 1938;110(24):2024. doi:10.1001/jama.1938.02790240048022

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Abstract

To the Editor:—  In The Journal a year ago (June 26, 1937, p. 2182) we reported that 1 per cent zinc sulfate solution thoroughly applied to the olfactory mucosa in monkeys affords a high degree of protection against poliomyelitis virus instilled intranasally a month later. Because susceptibility returned in most of the monkeys when they were retested some months later, and the anosmia following the application of zinc sulfate solution in man seemed to be only of temporary duration (Peet, M. M.; Echols, D. H., and Richter, H. J.: The Chemical Prophylaxis for Poliomyelitis, The Journal, June 26, 1937, p. 2184), we suggested a field test to determine the value of this solution in preventing the disease in man. Opportunities to carry out such tests appeared a few months later in several eastern cities. The results of one of these has been recently reported (Tisdall and others: Canad. Pub. Health

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