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June 11, 1938

Febrile Episoden bei schizophrenen Psychosen: Eine klinische und pathophysiologische Studie

JAMA. 1938;110(24):2031. doi:10.1001/jama.1938.02790240055033

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The author presents a study of a small series of psychoses classified as schizophrenic, with conspicuous somatic disturbances, especially fever, cyanosis and tachycardia. Detailed analysis of the changes in the blood picture, blood chemistry and cerebrospinal fluid were made in an attempt to discover the etiologic pathophysiologic process. The cases were selected to exclude all those in which any known exogenous toxic or infectious factors might be present. In the first group of febrile cyanotic psychoses, all acute or subacute, lasting from a few days to a few months, all terminating in coma and death, no adequate explanation of the disease was found at necropsy except dilatation of the heart and venous stasis. In all these cases, as in the cases of febrile and subfebrile episodes during the course of protracted schizophrenic psychoses, the author finds certain changes in the cellular and chemical constituents of the blood indicating a hemolytic

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