As a natural sequel to the discovery that nicotinic acid is highly effective in the cure of canine black-tongue1 and in the rapid relief of part at least of the syndrome of human pellagra,2 it was determined to test the potency of this substance as a preventive of relapse in known pellagrins. The present report deals with observations made on a group of such individuals under reasonably adequate control.
METHOD AND MATERIALS
Thirty-three patients were chosen from the files of an outpatient pellagra clinic which is conducted annually from March 1 to December 1 and which has some 350 clients. Only persons known to have had severe pellagra in previous years and showing definite symptoms of relapse on March 9, 1938, were selected for the experiment. Sixteen persons were given nicotinic acid; the remaining seventeen constituted a control group and were given the customary ration of brewers'
SCHMIDT HL, SYDENSTRICKER VP. NICOTINIC ACID IN THE PREVENTION OF PELLAGRAA PRELIMINARY NOTE. JAMA. 1938;110(25):2065–2066. doi:10.1001/jama.1938.02790250025007
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