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June 18, 1938


JAMA. 1938;110(25):2084. doi:10.1001/jama.1938.02790250044013

Investigations have established the essential role of the liver for maintaining the life processes. The clearcut results of hepatectomy and other experimental procedures leave little doubt that this organ is essential for the normal metabolism of the three so-called proximate principles the proteins, the carbohydrates and the lipids. Of the transformations occurring in the liver both under normal and under pathologic conditions, the alterations in lipid content are most striking. It is relatively simple to produce an increase in the quantity of liver lipids in normal animals by administration of diets containing either a high cholesterol or a high fat content. The ease with which this is produced makes available a ready means of determining experimentally the factors which may influence the deposition of lipids in the liver. The role of choline in this connection has already been discussed in these columns.1 More recently, experimental evidence has accumulated to

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