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July 16, 1938

HEREDITARY MULTIPLE TELANGIECTASIS WITH EPISTAXIS: METHOD OF TREATMENT

Author Affiliations

New York

From the Service of John D. Kernan, M.D., Columbia-Presbyterian Medical Center.

JAMA. 1938;111(3):242-244. doi:10.1001/jama.1938.72790290004007b
Abstract

Hereditary multiple telangiectasis with epistaxis, known also as Rendu-Osler-Weber disease, is a syndrome in which the terminal vessels, the capillaries and the venules become dilated.1 On microscopic examination these dilated vessels are found to have a single layer of endothelial cells covered by a very thin epithelium.2 As a result of this peculiar anatomic construction, these vessels readily become dilated and bleed profusely following the slightest trauma.

These lesions appear grossly as small red or purplish spots, usually occurring on the nasal mucosa of the septum and turbinates and sometimes occurring on the oral mucosa and skin as seen in this patient.2 It is known that the telangiectases may occur anywhere in the skin or mucous membranes and may become manifest as hematuria, gastrointestinal bleeding, uterine bleeding or epistaxis.1

This disease, unlike hemophilia, may be transmitted by either sex and may affect either the male or

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