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July 16, 1938


JAMA. 1938;111(3):256-257. doi:10.1001/jama.1938.02790290042015

Renal rickets, renal pseudorickets, renal dwarfism and renal infantilism are terms variously employed to designate a syndrome characterized by the combination of chronic renal disease and deformity of the bones. In 1870 Steiner and Neureutter reported finding six cases of granular atrophic kidney among 256 cases of nephritis in children in which necropsies were performed. Lucas in 1882 reported five cases in which late rickets was associated with albuminuria. He considered the cases to be true rickets and suggested for them the term "rickets of adolescence." More recent investigators, particularly Fletcher and Parsons, have recognized the etiologic relationship between chronic kidney disease and deformities of the bones. In 1930 Mitchell1 collected from the literature reports of seventy-six cases of renal rickets, to which he added two.

The symptomatology of this unusual condition is essentially that of nephrosclerosis associated with deformities of bone resembling true rickets. The sex distribution is