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July 30, 1932

THE CLINICAL SIGNIFICANCE OF VITAMIN D IN INFANCY AND CHILDHOOD

JAMA. 1932;99(5):384-388. doi:10.1001/jama.1932.27410570004009

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Abstract

The importance of vitamin D as an indispensable accessory food factor in proper growth and nutrition has been established beyond doubt by the most extensive scientific and clinical investigation. Beginning with the work of Mellanby in England, who first demonstrated that the experimental rickets of animals was controllable by the giving of cod liver oil or butter fat, there has been a steady accumulation of scientific facts and clinical data regarding this vitamin.

To McCollum and his co-workers belongs the credit of having first differentiated vitamin D from other accessory food factors and of having definitely established its identity. They also found that cod liver oil contained this factor in the highest degree and was practically a specific if high vitamin D effect was desired. This scientifically confirmed the experience of Nordic seafaring peoples that the oil of the liver of the cod was a potent remedy for many bodily

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