According to Walsh and Cannon1 of the departments of surgery and pathology, University of Chicago, regional vaccination is the method of choice in the attempt to increase the specific portal resistance of the upper respiratory tract. Local vaccination allegedly gives a much higher concentration of specific antibodies in respiratory tissues than that obtained by active or passive somatic immunization.
The initial studies of local immunity of respiratory tissues by Walsh and Cannon2 were made with type I pneumococcus infections in rabbits. They found that nasal instillation of relatively small volumes of virulent pneumococcus cultures into normal rabbits led to a fatal septicemia in about 90 per cent of the cases. Intranasal vaccination with a formaldehyde killed or autolyzed pneumococcus culture of the same type, however, conferred practically complete immunity against subsequent intranasal infection with the same strain. Local nonspecific irritants, such as alum, tannic acid or killed paratyphoid
LOCAL IMMUNIZATION OF THE NASAL MUCOSA. JAMA. 1938;111(9):848–849. doi:10.1001/jama.1938.02790350088014
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