This paper reports the results of treatment with the low cholesterol diet previously described by Twiss and Greene.1 One hundred cases of disease of the gallbladder associated with hypercholesteremia were studied. Eighty of the patients were treated medically with the low cholesterol diet; a control group of twenty-one patients with hypercholesteremia did not receive the low cholesterol diet. Twenty surgical patients with hypercholesteremia before operation received the low cholesterol diet after cholecystectomy; for control purposes there were fourteen similar surgical patients who did not have the low cholesterol diet. A further investigation was made of twelve cases in which hypercholesteremia developed only after cholecystectomy.
The principles of treatment (as described at the 1932 session of the American Medical Association) included the establishment of three types of diet designed to fit the needs of the patient with disease of the gallbladder. These needs were determined by a careful initial diagnostic
TWISS JR, BARNARD JH. DISEASE OF BILIARY TRACT ASSOCIATED WITH DISTURBANCES IN CHOLESTEROL METABOLISM. JAMA. 1938;111(11):990–994. doi:10.1001/jama.1938.02790370010003
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