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October 1, 1938


JAMA. 1938;111(14):1290-1298. doi:10.1001/jama.1938.72790400007010

The isolation, synthesis and development of practical methods of assay have given a great stimulus to the study of vitamin C.1 More papers have appeared on methods of assay and distribution for vitamin C than for all the other vitamins combined. Therefore, no attempt is made here to present a systematic review of the literature. This has been done amply in the monograph by Sherman and Smith,2 the yearly volumes of the Annual Review of Biochemistry,3 the bulletin of the United States Department of Agriculture on "Vitamin Content of Foods"4 and numerous reviews.5 The facts and comments presented in this review may serve to give a general idea of the present state of the subject.

BIO-ASSAY  Chemical methods have rapidly replaced vitamin C determinations by bio-assay for many types of investigations. However, the more specific animal tests continue to be necessary in order to avoid

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