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The first part of this monograph describes the clinical manifestations of neuropathic disturbances that develop in adult rats on a diet without vitamin E. These disturbances are prevented under certain conditions by a factor in wheat germ oil. The second part is devoted to a careful description of the extensive anatomic changes that may develop in the nervous system and skeletal muscles of adult rats fed without vitamin E. Whether the neurotropic principle in wheat germ oil is identical with vitamin E is not fully decided, but the facts at hand indicate that the two are identical.
Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats: A Neurotropic Factor in Wheat Germ Oil. JAMA. 1938;111(14):1321. doi:10.1001/jama.1938.02790400067033
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